Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial.

ABSTRACT:

Background

Observational studies suggested that a diet high in fruits and vegetables, both of which are rich with antioxidants, may prevent cancer development. However, findings from randomized trials of the association between antioxidant use and cancer risk have been mostly negative.

Methods

From 8171 women who were randomly assigned in the Women's Antioxidant Cardiovascular Study, a double-blind, placebo-controlled 2 x 2 x 2 factorial trial of vitamin C (500 mg of ascorbic acid daily), natural-source vitamin E (600 IU of alpha-tocopherol every other day), and beta carotene (50 mg every other day), 7627 women who were free of cancer before random assignment were selected for this study. Diagnoses and deaths from cancer at a specific site were confirmed by use of hospital r

SUBMITTER: Lin J 

PROVIDER: S-EPMC2615459 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature