Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.

ABSTRACT: Functional analysis of large gene lists, derived in most cases from emerging high-throughput genomic, proteomic and bioinformatics scanning approaches, is still a challenging and daunting task. The gene-annotation enrichment analysis is a promising high-throughput strategy that increases the likelihood for investigators to identify biological processes most pertinent to their study. Approximately 68 bioinformatics enrichment tools that are currently available in the community are collected in this survey. Tools are uniquely categorized into three major classes, according to their underlying enrichment algorithms. The comprehensive collections, unique tool classifications and associated questions/issues will provide a more comprehensive and up-to-date view regarding the advantages, pitfalls

SUBMITTER: Huang da W 

PROVIDER: S-EPMC2615629 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature