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Low temperature organocopper-mediated two-component cross coupling/cycloisomerization approach toward N-fused heterocycles.


ABSTRACT: Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an SN2' substitution followed by a subsequent cycloisomerization step.

SUBMITTER: Chernyak D 

PROVIDER: S-EPMC2615671 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Low temperature organocopper-mediated two-component cross coupling/cycloisomerization approach toward N-fused heterocycles.

Chernyak Dmitri D   Gadamsetty Surendra Babu SB   Gevorgyan Vladimir V  

Organic letters 20080508 11


Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an SN2' substitution followed by a subsequent cycloisomerization step. ...[more]

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