Mononucleotide repeats are asymmetrically distributed in fungal genes.

ABSTRACT:

Background

Systematic analyses of sequence features have resulted in a better characterisation of the organisation of the genome. A previous study in prokaryotes on the distribution of sequence repeats, which are notoriously variable and can disrupt the reading frame in genes, showed that these motifs are skewed towards gene termini, specifically the 5' end of genes. For eukaryotes no such intragenic analysis has been performed, though this could indicate the pervasiveness of this distribution bias, thereby helping to expose the selective pressures causing it.

Results

In fungal gene repertoires we find a similar 5' bias of intragenic mononucleotide repeats, most notably for Candida spp., whereas e.g. Coccidioides spp. display no such bias. With increasing repeat length, ever

SUBMITTER: van Passel MW 

PROVIDER: S-EPMC2621210 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature