Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.
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ABSTRACT:
SUBMITTER: Meira LB
PROVIDER: S-EPMC2621254 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.
Meira Lisiane B LB Moroski-Erkul Catherine A CA Green Stephanie L SL Calvo Jennifer A JA Bronson Roderick T RT Shah Dharini D Samson Leona D LD
Proceedings of the National Academy of Sciences of the United States of America 20090112 3
Vision loss affects >3 million Americans and many more people worldwide. Although predisposing genes have been identified their link to known environmental factors is unclear. In wild-type animals DNA alkylating agents induce photoreceptor apoptosis and severe retinal degeneration. Alkylation-induced retinal degeneration is totally suppressed in the absence of the DNA repair protein alkyladenine DNA glycosylase (Aag) in both differentiating and postmitotic retinas. Moreover, transgenic expressio ...[more]
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