The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: a meta-analysis.

ABSTRACT:

Background

Because of recent concerns about the safety of aprotinin, we updated our 2007 Cochrane review that compared the relative benefits and risks of aprotinin and the lysine analogues tranexamic acid and epsilon aminocaproic acid.

Methods

We searched electronic databases, including CENTRAL, MEDLINE, EMBASE, Google and Google Scholar for trials of antifibrinolytic drugs used in adults scheduled for cardiac surgery. Searches were updated to January 2008. By comparing aprotinin and the 2 lysine analogues to control, we derived indirect head-to-head comparisons of aprotinin to the other drugs. We derived direct estimates of risks and benefits by pooling estimates from head-to-head trials of aprotinin and tranexamic acid or epsilon aminocaproic acid.

Results

For indir

SUBMITTER: Henry D 

PROVIDER: S-EPMC2621296 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature