Uptake and intra-inclusion accumulation of exogenous immunoglobulin by Chlamydia-infected cells.

ABSTRACT:

Background

Obligate intracellular pathogens belonging to the Chlamydiaceae family possess a number of mechanisms by which to manipulate the host cell and surrounding environment. Such capabilities include the inhibition of apoptosis, down-regulation of major histocompatability complex (MHC) and CD1/d gene expression, and the acquisition of host-synthesized nutrients. It is also documented that a limited number of host-derived macromolecules such as beta-catenin and sphingomyelin accumulate within the inclusion.

Results

This report provides evidence that immunoglobulin, inherently present in the extracellular environment in vivo and in vitro, enters infected cells and accumulates within the chlamydial inclusion. Using epi-fluorescent and confocal microscopy, this selective up

SUBMITTER: Pollack DV 

PROVIDER: S-EPMC2621372 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature