Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis.

ABSTRACT: The final step during cell division is the separation of daughter cells, a process that requires the coordinated delivery and assembly of new membrane to the cleavage furrow. While most eukaryotic cells replicate by binary fission, replication of apicomplexan parasites involves the assembly of daughters (merozoites/tachyzoites) within the mother cell, using the so-called Inner Membrane Complex (IMC) as a scaffold. After de novo synthesis of the IMC and biogenesis or segregation of new organelles, daughters bud out of the mother cell to invade new host cells. Here, we demonstrate that the final step in parasite cell division involves delivery of new plasma membrane to the daughter cells, in a process requiring functional Rab11A. Importantly, Rab11A can be found in association with Myosin-Ta

SUBMITTER: Agop-Nersesian C 

PROVIDER: S-EPMC2622761 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature