Retrospective analysis of a local cessation of vaccination against poliomyelitis: a possible scenario for the future.

ABSTRACT: The global eradication of poliomyelitis will require substantial changes in immunization practices. One of the proposed scenarios includes cessation of vaccination with live oral poliovirus vaccine (OPV) and the creation of an OPV stockpile for emergency response in case of the reintroduction of poliovirus into circulation. We describe here a retrospective analysis of the cessation of OPV usage in a region of the Byelorussian Republic of the former Soviet Union in 1963 to 1966. During this period, a widespread circulation and evolution of independent lineages of vaccine-derived polioviruses took place in the region. Some of these lineages appeared to originate from OPV given to 40 children in the community during this period of essentially no vaccinations. The data demonstrate very high ri

SUBMITTER: Korotkova EA 

PROVIDER: S-EPMC262597 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature