Behavioral economic assessment of price and cocaine consumption following self-administration histories that produce escalation of either final ratios or intake.

ABSTRACT: Various self-administration procedures are being developed to model specific aspects of the addiction process. For example, 'increased cocaine intake over time' has been modeled by providing long access (LgA) to cocaine during daily self-administration sessions under a fixed-ratio (FR1) reinforcement schedule. In addition, 'increased time and energy devoted to acquire cocaine' has been modeled by providing access to cocaine during daily self-administration sessions under a progressive-ratio (PR) schedule. To investigate the distinctiveness of these models, the behavioral economics variables of consumption and price were applied to cocaine self-administration data. To assess changes in consumption and price, cocaine self-administration was tested across a descending series of doses (0.237-0

SUBMITTER: Oleson EB 

PROVIDER: S-EPMC2626138 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature