Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.

ABSTRACT:

Context

Over the last few months, genome-wide association studies have contributed significantly to our understanding of the genetic architecture of type 2 diabetes. If and how this information will impact clinical practice is not yet clear.

Evidence acquisition

Primary papers reporting genome-wide association studies in type 2 diabetes or establishing a reproducible association for specific candidate genes were compiled. Further information was obtained from background articles, authoritative reviews, and relevant meeting conferences and abstracts.

Evidence synthesis

As many as 17 genetic loci have been convincingly associated with type 2 diabetes; 14 of these were not previously known, and most of them were unsuspected. The associated polymorphisms are common in pop

SUBMITTER: Florez JC 

PROVIDER: S-EPMC2626447 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature