Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans.

ABSTRACT:

Context

ATP-sensitive potassium channels are composed of pore-forming (Kir6.x) and regulatory sulfonylurea receptor (SURx) subunits and have been implicated in the maintenance of glucose homeostasis. Kir6.2 and SUR1 are expressed in a broad range of tissues, and no contemporary studies have addressed the physiological impact of variants in Hispanic-Americans and African-Americans carefully phenotyped for components of glucose homeostasis.

Objective

The objective of this study was to evaluate two nonsynonymous variants in Kir6.2 (E23K) and SUR1 (A1369S) and determine their role in vivo.

Design and setting

The Insulin Resistance Atherosclerosis Family Study (IRAS-FS) is a community-based study of Hispanic-Americans (San Antonio, TX, and San Luis Valley, CO) and African-

SUBMITTER: Palmer ND 

PROVIDER: S-EPMC2626454 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature