The syndromic management of vaginal discharge using single-dose treatments: a randomized controlled trial in West Africa.

ABSTRACT:

Objective

To evaluate whether single-dose treatments are as effective as standard therapy in the syndromic management of vaginal discharge.

Methods

A randomized controlled effectiveness trial compared single-dose tinidazole plus fluconazole (TF) with treatment for 7 days with metronidazole plus 3 days of treatment with vaginal clotrimazole (MC) among 1570 women presenting with vaginal discharge at primary health care institutions in Ghana, Guinea, Mali and Togo. Participants were randomly allocated to one of the two treatments by research nurses or physicians using precoded envelopes. Effectiveness was assessed by symptomatic response on day 14. CLINICAL IDENTIFIER ClinicalTrials.gov NCT00313131.

Findings

The two treatment regimens had similar effectiveness: complete

SUBMITTER: Pepin J 

PROVIDER: S-EPMC2627470 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature