Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.

ABSTRACT:

Background

Uncoupling protein 1 (UCP1) is a mitochondrial anion carrier, expressed in brown adipose tissue (BAT) of Eutherians. UCP1 is responsible for uncoupling mitochondrial proton transport from the production of ATP, thereby dissipating heat; it is essential for non-shivering thermogenesis (NST) in mammalian BAT. UCP1 orthologs have been identified in non-Eutherian mammals, fish and amphibians. Yet, UCP1 has a unique function in Eutherians in that it is necessary in the production of heat (NST). As such, this study aims to determine the evolutionary mode of UCP1 in Eutherians, where there is clear evidence of UCP1-dependent NST in BAT.

Results

Models of adaptive evolution through phylogenetic analysis of amino acid sequences by maximum likelihood were implemented to det

SUBMITTER: Hughes DA 

PROVIDER: S-EPMC2627829 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature