One-month diesel exhaust inhalation produces hypertensive gene expression pattern in healthy rats.

ABSTRACT:

Background

Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial dysfunction, and myocardial ischemia in compromised individuals.

Objective

We hypothesized that DE inhalation would cause greater inflammation, hematologic alterations, and cardiac molecular impairment in spontaneously hypertensive (SH) rats than in healthy Wistar Kyoto (WKY) rats.

Methods and results

Male rats (12-14 weeks of age) were exposed to air or DE from a 30-kW Deutz engine at 500 or 2,000 microg/m3, 4 hr/day, 5 days/week for 4 weeks. Neutrophilic influx was noted in the lung lavage fluid of both strains, but injury markers were minimally changed. Particle-laden macrophages were apparent histologically in DE-exposed rats. Lower baseline cardiac anti-oxidant enzyme activities

SUBMITTER: Gottipolu RR 

PROVIDER: S-EPMC2627863 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature