Global transcriptional profiling reveals Streptococcus agalactiae genes controlled by the MtaR transcription factor.

ABSTRACT:

Background

Streptococcus agalactiae (group B Streptococcus; GBS) is a significant bacterial pathogen of neonates and an emerging pathogen of adults. Though transcriptional regulators are abundantly encoded on the GBS genome, their role in GBS pathogenesis is poorly understood. The mtaR gene encodes a putative LysR-type transcriptional regulator that is critical for the full virulence of GBS. Previous studies have shown that an mtaR- mutant transports methionine at reduced rates and grows poorly in normal human plasma not supplemented with methionine. The decreased virulence of the mtaR mutant was correlated with a methionine transport defect; however, no MtaR-regulated genes were identified.

Results

Microarray analysis of wild-type GBS and an mtaR mutant revealed differentia

SUBMITTER: Bryan JD 

PROVIDER: S-EPMC2627894 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature