Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation.

ABSTRACT:

Background

One mechanism to account for robustness against gene knockouts or knockdowns is through buffering by gene duplicates, but the extent and general correlates of this process in organisms is still a matter of debate. To reveal general trends of this process, we provide a comprehensive comparison of gene essentiality, duplication and buffering by duplicates across seven bacteria (Mycoplasma genitalium, Bacillus subtilis, Helicobacter pylori, Haemophilus influenzae, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Escherichia coli), and four eukaryotes (Saccharomyces cerevisiae (yeast), Caenorhabditis elegans (worm), Drosophila melanogaster (fly), Mus musculus (mouse)).

Results

In nine of the eleven organisms, duplicates significantly increase chances of survival up

SUBMITTER: Hannay K 

PROVIDER: S-EPMC2627895 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature