Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer.

ABSTRACT:

Background

Persistent colonization of the human stomach by Helicobacter pylori is associated with asymptomatic gastric inflammation (gastritis) and an increased risk of duodenal ulceration, gastric ulceration, and non-cardia gastric cancer. In previous studies, the genome sequences of H. pylori strains from patients with gastritis or duodenal ulcer disease have been analyzed. In this study, we analyzed the genome sequences of an H. pylori strain (98-10) isolated from a patient with gastric cancer and an H. pylori strain (B128) isolated from a patient with gastric ulcer disease.

Results

Based on multilocus sequence typing, strain 98-10 was most closely related to H. pylori strains of East Asian origin and strain B128 was most closely related to strains of European origin. Str

SUBMITTER: McClain MS 

PROVIDER: S-EPMC2627912 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature