Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: synchronous and differential responses.

ABSTRACT:

Background

The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is now well established. It raises concerns for the interpretation of risks arising from exposure to low doses of ionizing radiation. However, the regulatory mechanisms involved in the bystander response have not been well elucidated. To provide insight into the signaling pathways responding in bystanders, we have measured global gene expression four hours after bystander and direct alpha particle exposure of primary human lung fibroblasts.

Results

Although common p53-regulated radiation response genes like CDKN1A were expressed at elevated levels in the directly exposed cultures, they showed little or no change in the bystanders. In contrast, gen

SUBMITTER: Ghandhi SA 

PROVIDER: S-EPMC2627914 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature