Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex.

ABSTRACT:

Background

The Burkholderia cepacia complex (BCC) is a versatile group of Gram negative organisms that can be found throughout the environment in sources such as soil, water, and plants. While BCC bacteria can be involved in beneficial interactions with plants, they are also considered opportunistic pathogens, specifically in patients with cystic fibrosis and chronic granulomatous disease. These organisms also exhibit resistance to many antibiotics, making conventional treatment often unsuccessful. KS10 was isolated as a prophage of B. cenocepacia K56-2, a clinically relevant strain of the BCC. Our objective was to sequence the genome of this phage and also determine if this prophage encoded any virulence determinants.

Results

KS10 is a 37,635 base pairs (bp) transposable ph

SUBMITTER: Goudie AD 

PROVIDER: S-EPMC2628397 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature