Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy.

ABSTRACT:

Objective

Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations.

Research design and methods

A comprehensive association analysis of 24 single-nucleotide polymorphisms (SNPs) in the adiponectin gene was performed for type 2 diabetes and diabetic nephropathy in African Americans.

Results

The minor allele (A) in a single SNP in intron 1 (rs182052) was associated with diabetic nephropathy (P = 0.0015, odds ratio [OR] 1.37, CI 1.13-1.67, dominant model) in an African American sample of 851 case subjects with diabetic nephropathy and 871 nondiabetic control subjects in analyses incorporating adjustment for varying levels of racial admixture. This associati

SUBMITTER: Bostrom MA 

PROVIDER: S-EPMC2628626 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature