Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

ABSTRACT:

Objective

This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes association and considered the implications for the etiological heterogeneity of type 2 diabetes.

Research design and methods

We reanalyzed data from the Wellcome Trust Case Control Consortium genome-wide association scan (1,924 case subjects, 2,938 control subjects: 393,453 single-nucleotide polymorphisms [SNPs]) after stratifying case subjects (into "obese" and "nonobese") according to median BMI (30.2 kg/m(2)). Replication of signals in which alternative case-ascertainment strategies generated marked effect size heterogeneity in type 2 diabetes association signal was sought in additional samples.

Results

In the "obe

SUBMITTER: Timpson NJ 

PROVIDER: S-EPMC2628627 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature