Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats.

ABSTRACT:

Background

Mesothelin is a 40 kDa protein present on the surface of normal mesothelial cells and overexpressed in many human tumours, including mesothelioma and ovarian and pancreatic adenocarcinoma. It forms a strong and specific complex with MUC16, which is also highly expressed on the surface of mesothelioma and ovarian cancer cells. This binding has been suggested to be the basis of ovarian cancer metastasis. Knowledge of the structure of this protein will be useful, for example, in building a structural model of the MUC16-mesothelin complex. Mesothelin is produced as a precursor, which is cleaved by furin to produce the N-terminal half, which is called the megakaryocyte potentiating factor (MPF), and the C-terminal half, which is mesothelin. Little is known about the function

SUBMITTER: Sathyanarayana BK 

PROVIDER: S-EPMC2628672 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature