Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.

ABSTRACT:

Background

Catecholamines govern stress blood pressure responses. Catecholaminergic responses may be partially genetic and contribute to the complex heritability of hypertension.

Methods and results

To evaluate catecholaminergic responses without systemic counterregulation, we infused graded concentrations of tyramine, an indirect presynaptic norepinephrine releaser, into dorsal hand veins of 49 normotensive men and women of 5 ethnicities. Vascular responses were coupled to common (minor allele frequency >10%) single-nucleotide polymorphisms at adrenergic target loci within presynaptic pathways. Significance was set at P<0.003 after Bonferroni correction. Generalized analysis of molecular variance (GAMOVA) was performed to determine whether genetic admixture contributed to r

SUBMITTER: Fung MM 

PROVIDER: S-EPMC2628716 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature