Statistical analysis of physical-chemical properties and prediction of protein-protein interfaces.

ABSTRACT: We have developed a fully automated method, InterProSurf, to predict interacting amino acid residues on protein surfaces of monomeric 3D structures. Potential interacting residues are predicted based on solvent accessible surface areas, a new scale for interface propensities, and a cluster algorithm to locate surface exposed areas with high interface propensities. Previous studies have shown the importance of hydrophobic residues and specific charge distribution as characteristics for interfaces. Here we show differences in interface and surface regions of all physical chemical properties of residues as represented by five quantitative descriptors. In the current study a set of 72 protein complexes with known 3D structures were analyzed to obtain interface propensities of residues, and to

SUBMITTER: Negi SS 

PROVIDER: S-EPMC2628805 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature