Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus.

ABSTRACT:

Background

Mus spretus diverged from Mus musculus over one million years ago. These mice are genetically and phenotypically divergent. Despite the value of utilizing M. musculus and M. spretus for quantitative trait locus (QTL) mapping, relatively little genomic information on M. spretus exists, and most of the available sequence and polymorphic data is for one strain of M. spretus, Spret/Ei. In previous work, we mapped fifteen loci for skin cancer susceptibility using four different M. spretus by M. musculus F1 backcrosses. One locus, skin tumor susceptibility 5 (Skts5) on chromosome 12, shows strong linkage in one cross.

Results

To identify potential candidate genes for Skts5, we sequenced 65 named and unnamed genes and coding elements mapping to the peak linkage area in o

SUBMITTER: Mahler KL 

PROVIDER: S-EPMC2628916 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature