Transcriptome profiling of the feeding-to-fasting transition in chicken liver.

ABSTRACT:

Background

Starvation triggers a complex array of adaptative metabolic responses including energy-metabolic responses, a process which must imply tissue specific alterations in gene expression and in which the liver plays a central role. The present study aimed to describe the evolution of global gene expression profiles in liver of 4-week-old male chickens during a 48 h fasting period using a chicken 20 K oligoarray.

Results

A large number of genes were modulated by fasting (3532 genes with a pvalue corrected by Benjamini-Hochberg < 0.01); 2062 showed an amplitude of variation higher than +/- 40% among those, 1162 presented an human ortholog, allowing to collect functional information. Notably more genes were down-regulated than up-regulated, whatever the duration of fastin

SUBMITTER: Desert C 

PROVIDER: S-EPMC2628918 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature