Biological processes, properties and molecular wiring diagrams of candidate low-penetrance breast cancer susceptibility genes.

ABSTRACT:

Background

Recent advances in whole-genome association studies (WGASs) for human cancer risk are beginning to provide the part lists of low-penetrance susceptibility genes. However, statistical analysis in these studies is complicated by the vast number of genetic variants examined and the weak effects observed, as a result of which constraints must be incorporated into the study design and analytical approach. In this scenario, biological attributes beyond the adjusted statistics generally receive little attention and, more importantly, the fundamental biological characteristics of low-penetrance susceptibility genes have yet to be determined.

Methods

We applied an integrative approach for identifying candidate low-penetrance breast cancer susceptibility genes, their charac

SUBMITTER: Bonifaci N 

PROVIDER: S-EPMC2628924 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature