Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk.

ABSTRACT:

Background

Matrix metalloproteases (MMPs) constitute a family of enzymes capable of degrading different components of the extracellular matrix and are implicated in the invasion of tumor cells through the basement membrane. Polymorphisms in MMP genes may result in changes in the expression of MMPs being associated with the development and progression of cancer. We have investigated the association between three polymorphisms (-1607 1G/2G, +17 C/G and -77 A/G) in the human collagenases MMP1, MMP8 and MMP13 and the risk of development or progression of lung cancer.

Methods

A hospital-based case-control study was designed including 501 lung cancer patients and 510 controls matched. Genotypes were determined by PCR-RFLP. Results were analyzed using unconditional logistic regress

SUBMITTER: Gonzalez-Arriaga P 

PROVIDER: S-EPMC2628929 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature