Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling.

ABSTRACT:

Purpose

Our understanding of adrenocortical carcinoma (ACC) has improved considerably, yet many unanswered questions remain. For instance, can molecular subtypes of ACC be identified? If so, what is their underlying pathogenetic basis and do they possess clinical significance?

Experimental design

We did a whole genome gene expression study of a large cohort of adrenocortical tissues annotated with clinicopathologic data. Using Affymetrix Human Genome U133 Plus 2.0 oligonucleotide arrays, transcriptional profiles were generated for 10 normal adrenal cortices (NC), 22 adrenocortical adenomas (ACA), and 33 ACCs.

Results

The overall classification of adrenocortical tumors was recapitulated using principal component analysis of the entire data set. The NC and ACA cohorts s

SUBMITTER: Giordano TJ 

PROVIDER: S-EPMC2629378 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature