Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3.

ABSTRACT:

Background

Although genetic variation at chromosome 9p21.3 is associated with incident cardiovascular disease, it is unclear whether screening for this polymorphism improves risk prediction.

Objective

To determine whether knowledge of variation at chromosome 9p21.3 provides predictive information beyond that from other readily available risk factors.

Design

Prospective cohort study.

Setting

United States.

Patients

22 129 female white health professionals participating in the Women's Genome Health Study, initially without any major chronic disease, who were prospectively followed over a median of 10.2 years for incident cardiovascular disease.

Measurements

Polymorphism at rs10757274 in chromosome 9p21.3 and additional cardiovascular disease risk fa

SUBMITTER: Paynter NP 

PROVIDER: S-EPMC2629586 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature