Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.

ABSTRACT:

Background

Understanding the molecular control of cell lineages and fate determination in complex tissues is key to not only understanding the developmental biology and cellular homeostasis of such tissues but also for our understanding and interpretation of the molecular pathology of diseases such as cancer. The prerequisite for such an understanding is detailed knowledge of the cell types that make up such tissues, including their comprehensive molecular characterisation. In the mammary epithelium, the bulk of the tissue is composed of three cell lineages, namely the basal/myoepithelial, luminal epithelial estrogen receptor positive and luminal epithelial estrogen receptor negative cells. However, a detailed molecular characterisation of the transcriptomic differences between the

SUBMITTER: Kendrick H 

PROVIDER: S-EPMC2629782 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature