Airways inflammation and treatment during acute exacerbations of COPD.

ABSTRACT:

Introduction

Inflammation is a core feature of acute chronic obstructive pulmonary disease (COPD) exacerbations. It is important to focus on inflammation since it gives insight into the pathological changes causing an exacerbation, thereby possibly providing directions for future therapies which modify inflammation.

Objectives

To provide a cell-by-cell overview of the inflammatory processes during COPD exacerbations. To evaluate cell activation, and cytokine production, cellular interactions, damaging effects of inflammatory mediators to tissue, and the relation to symptoms at the onset of COPD exacerbations. To speculate on future therapeutic options to modify inflammation during COPD exacerbations.

Results

During COPD exacerbations, there is increased airway wall in

SUBMITTER: Bathoorn E 

PROVIDER: S-EPMC2629961 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature