STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

ABSTRACT:

Background

Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q.

Methods

We tested single-nucleotide polymorphisms (SNPs) in and around 13 candidate genes within the previously linked chromosome 2q region for association with rheumatoid arthritis. We then performed fine mapping of the STAT1-STAT4 region in a total of 1620 case patients with established rheumatoid arthritis and 2635 controls, all from North America. Implicated SNPs were further tested in an independent case-control series of 1529 patients with early rheumatoid arthritis and 881 controls, all from Sweden, and in a total of 1039 case patients and 1248 controls from three series of patients with syste

SUBMITTER: Remmers EF 

PROVIDER: S-EPMC2630215 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature