Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C.

ABSTRACT: The dynamics of the viral decline immediately after the start of therapy for chronic hepatitis C virus (HCV) infection may have prognostic potential for ultimate sustained virologic response. Considerable interindividual variability in the decline has been reported, including differences by race. The human major histocompatability complex (MHC) genes encode the human leukocyte antigens, which are important in the immune response to viral infections. We examined whether carriage of specific human MHC alleles are associated with the rate of the early viral decline. Longitudinal viral level data (baseline and days 1, 2, 7, 14, and 28 of treatment), medium resolution MHC genotyping, and random coefficients models were used to examine associations between MHC class I and class II allele carriag

SUBMITTER: Yee LJ 

PROVIDER: S-EPMC2630649 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature