A synthetic surface that undergoes spatiotemporal remodeling.

ABSTRACT: The ability to undergo spatially resolved remodeling within defined time domains is one of the ubiquitous features of nature. In fact, essentially any biological structure undergoes defined molecular interactions and exhibits lateral mobility within defined time domains. The impartment of surface mobility has therefore emerged as one of the key challenges, when engineering synthetic analogues of natural biointerfaces. Herein, we report a synthetic analogue based on self-assembled monolayers that can undergo spatial remodeling on demand, thereby mimicking nature's spatiotemporally controlled biointerfaces. First, we created microstructured surfaces, where the structural differences between regions originated from differences in the molecular density of the nanofilm, while the chemical compo

SUBMITTER: Peng DK 

PROVIDER: S-EPMC2630857 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature