Effect of tumor necrosis factor-alpha on estrogen metabolism and endometrial cells: potential physiological and pathological relevance.

ABSTRACT:

Context

Estrogen and its metabolites play a critical role in the pathophysiology of the endometrium. The bioavailability of estrogen and estrogen metabolites in endometrial tissues depends on the expression of enzymes involved in estrogen biosynthesis and metabolism. Substantial evidence indicates that estrogen-dependent endometrial disorders are also associated with proinflammatory milieu. However, the mechanism whereby inflammation contributes to these conditions is not known.

Objective

The objective of the study was to investigate the effect of TNF-alpha on estrogen metabolism and the expression of estrogen-metabolizing genes in human endometrial glandular epithelial cells (EM1).

Design

EM1 were treated with 17beta-estradiol (E2) with or without TNF-alpha. Capillar

SUBMITTER: Salama SA 

PROVIDER: S-EPMC2630861 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature