Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.

ABSTRACT:

Context

The glucocorticoid receptor (GR) is a key hormone in the hypothalamus-pituitary-adrenal axis that regulates many pathways including blood pressure homeostasis. Thus, GR gene variation may influence interindividual differences in blood pressure in human populations.

Objective

We resequenced individual GR alleles for comprehensive discovery of GR variants and their chromosomal phase in three major American ethnic groups. We examined the influence of GR variants on blood pressure in large numbers of families using family-based association methods.

Design and participants

For association studies, we genotyped GR variants in family members from the Genetic Epidemiology Network of Arteriopathy (GENOA) study that were measured for multiple blood pressure traits. The

SUBMITTER: Chung CC 

PROVIDER: S-EPMC2630865 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature