Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance.

ABSTRACT:

Objective

The potential differential contributions of skeletal muscle and adipose tissue to whole body insulin resistance were evaluated in subjects with polycystic ovary syndrome (PCOS).

Research design and methods

Forty-two PCOS subjects and 15 body mass index-matched control subjects were studied. Insulin action was evaluated by the hyperinsulinemic/euglycemic clamp procedure. Isolated adipocytes and cultured muscle cells were analyzed for glucose transport activity; adipocytes, muscle tissue, and myotubes were analyzed for the expression and phosphorylation of insulin-signaling proteins.

Results

Fifty-seven per cent of the PCOS subjects had impaired glucose tolerance and the lowest rate of maximal insulin-stimulated whole body glucose disposal compared to controls

SUBMITTER: Ciaraldi TP 

PROVIDER: S-EPMC2630871 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature