Regenerative potentials of the murine thyroid in experimental autoimmune thyroiditis: role of CD24.

ABSTRACT: Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. This experimental autoimmune thyroiditis (EAT) model has been extensively characterized during early disease phases (up to d 35 after immunization). By extending the analysis of EAT to 100 d after immunization, we noted a remarkable regenerative capacity of the thyroid and the expression of Oct-4, suggesting in vivo the existence of adult thyroid stem cells. After an almost complete destruction of the follicular architecture, occurring between d 21 and 28, the thyroid was capable of restoring its follicles and reducing the mononuclear infiltration, so that by d 100 after immunization, it regained its normal morphology and function. During this regeneration proces

SUBMITTER: Chen CY 

PROVIDER: S-EPMC2630910 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature