Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population.

ABSTRACT:

Background

The alpha1A-adrenergic receptor (alpha1A-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we aimed to investigate the association between the Arg347Cys polymorphism in the alpha1A-AR gene and blood pressure phenotypes, in a large sample of Brazilians from an urban population.

Methods

A total of 1568 individuals were randomly selected from the general population of the Vitória City metropolitan area. Genetic analysis of the Arg347Cys polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism. We have compared cardiovascular risk variables and genotypes using ANOVA, and Chi-square test for univariate compariso

SUBMITTER: Freitas SR 

PROVIDER: S-EPMC2630987 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature