Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality.

ABSTRACT:

Background

Gene expression is controlled over a wide range at the transcript level through complex interplay between DNA and regulatory proteins, resulting in profiles of gene expression that can be represented as normal, graded, and bimodal (switch-like) distributions. We have previously performed genome-scale identification and annotation of genes with switch-like expression at the transcript level in mouse, using large microarray datasets for healthy tissue, in order to study the cellular pathways and regulatory mechanisms involving this class of genes. We showed that a large population of bimodal mouse genes encoding for cell membrane and extracellular matrix proteins is involved in communication pathways. This study expands on previous results by annotating human bimodal genes

SUBMITTER: Ertel A 

PROVIDER: S-EPMC2631022 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature