Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure.
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ABSTRACT:
SUBMITTER: Brown JD
PROVIDER: S-EPMC2631080 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure.
Brown Jacob D JD Dutta Sunit S Bharti Kapil K Bonner Robert F RF Munson Peter J PJ Dawid Igor B IB Akhtar Amana L AL Onojafe Ighovie F IF Alur Ramakrishna P RP Gross Jeffrey M JM Hejtmancik J Fielding JF Jiao Xiaodong X Chan Wai-Yee WY Brooks Brian P BP
Proceedings of the National Academy of Sciences of the United States of America 20090126 5
The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. Here, we profile global gene expression during optic fissure closure using laser capture microdissected (LCM) tissue from the margins of the fissure. From these data, we identify a unique role for the C(2)H(2) zinc finger proteins Nlz1 and Nlz2 in normal fissure closure. Gene knockdown of nlz1 and/or nlz2 in zebrafish leads to a failure of the optic fissure to close, a phenotype whi ...[more]
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