Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium.

ABSTRACT: The bone marrow compartment is enriched in stem and progenitor cells, and an unidentified subpopulation of these cells can contribute to lung epithelial repair. Here we identify this subpopulation and quantitate its relative contribution to injured airway epithelium. A subpopulation of adherent human and murine bone marrow cells that expresses Clara cell secretory protein (CCSP) was identified using flow cytometry. When cultured at the air-liquid interface in ex vivo cultures, Ccsp+ cells expressed type I and type II alveolar markers as well as basal cell markers and active epithelial sodium channels. Ccsp+ cells preferentially homed to naphthalene-damaged airways when delivered transtracheally or intravenously, with the former being more efficient than the latter. Interestingly, naphthale

SUBMITTER: Wong AP 

PROVIDER: S-EPMC2631300 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature