Synthetic control of a fitness tradeoff in yeast nitrogen metabolism.

ABSTRACT:

Background

Microbial communities are involved in many processes relevant to industrial and medical biotechnology, such as the formation of biofilms, lignocellulosic degradation, and hydrogen production. The manipulation of synthetic and natural microbial communities and their underlying ecological parameters, such as fitness, evolvability, and variation, is an increasingly important area of research for synthetic biology.

Results

Here, we explored how synthetic control of an endogenous circuit can be used to regulate a tradeoff between fitness in resource abundant and resource limited environments in a population of Saccharomyces cerevisiae. We found that noise in the expression of a key enzyme in ammonia assimilation, Gdh1p, mediated a tradeoff between growth in low nitroge

SUBMITTER: Bayer TS 

PROVIDER: S-EPMC2631470 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature