Comparison of public peak detection algorithms for MALDI mass spectrometry data analysis.

ABSTRACT:

Background

In mass spectrometry (MS) based proteomic data analysis, peak detection is an essential step for subsequent analysis. Recently, there has been significant progress in the development of various peak detection algorithms. However, neither a comprehensive survey nor an experimental comparison of these algorithms is yet available. The main objective of this paper is to provide such a survey and to compare the performance of single spectrum based peak detection methods.

Results

In general, we can decompose a peak detection procedure into three consequent parts: smoothing, baseline correction and peak finding. We first categorize existing peak detection algorithms according to the techniques used in different phases. Such a categorization reveals the differences and si

SUBMITTER: Yang C 

PROVIDER: S-EPMC2631518 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature