OxyGene: an innovative platform for investigating oxidative-response genes in whole prokaryotic genomes.

ABSTRACT:

Background

Oxidative stress is a common stress encountered by living organisms and is due to an imbalance between intracellular reactive oxygen and nitrogen species (ROS, RNS) and cellular antioxidant defence. To defend themselves against ROS/RNS, bacteria possess a subsystem of detoxification enzymes, which are classified with regard to their substrates. To identify such enzymes in prokaryotic genomes, different approaches based on similarity, enzyme profiles or patterns exist. Unfortunately, several problems persist in the annotation, classification and naming of these enzymes due mainly to some erroneous entries in databases, mistake propagation, absence of updating and disparity in function description.

Description

In order to improve the current annotation of oxidative

SUBMITTER: Thybert D 

PROVIDER: S-EPMC2631583 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature