Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression.

ABSTRACT:

Background

In man, infection by the Gram-negative enteropathogen Yersinia pseudotuberculosis is usually limited to the terminal ileum. However, in immunocompromised patients, the microorganism may disseminate from the digestive tract and thus cause a systemic infection with septicemia.

Results

To gain insight into the metabolic pathways and virulence factors expressed by the bacterium at the blood stage of pseudotuberculosis, we compared the overall gene transcription patterns (the transcriptome) of bacterial cells cultured in either human plasma or Luria-Bertani medium. The most marked plasma-triggered metabolic consequence in Y. pseudotuberculosis was the switch to high glucose consumption, which is reminiscent of the acetogenic pathway (known as "glucose overflow") in Esc

SUBMITTER: Rosso ML 

PROVIDER: S-EPMC2631605 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature