The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?

ABSTRACT: In follow-up from evidence obtained in linkage studies, systematic linkage disequilibrium mapping within chromosomal region 13q33 has led to the identification of a schizophrenia susceptibility locus which harbors the genes G72 and G30. These association findings have been replicated in several independent schizophrenia samples. Association has also been found between genetic variants at the G72/G30 locus and bipolar affective disorder (BPAD), with replication in independent studies. Results from studies of more detailed psychiatric phenotypes show that association exists with symptom clusters that are common to several disorders as well as with specific psychiatric diagnoses. These findings may indicate that the association lies not with the diagnostic categories per se but with more spec

SUBMITTER: Abou Jamra R 

PROVIDER: S-EPMC2632259 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature