Phylogenetic distribution and membrane topology of the LytR-CpsA-Psr protein family.

ABSTRACT:

Background

The bacterial cell wall is the target of many antibiotics and cell envelope constituents are critical to host-pathogen interactions. To combat resistance development and virulence, a detailed knowledge of the individual factors involved is essential. Members of the LytR-CpsA-Psr family of cell envelope-associated attenuators are relevant for beta-lactam resistance, biofilm formation, and stress tolerance, and they are suggested to play a role in cell wall maintenance. However, their precise function is still unknown. This study addresses the occurrence as well as sequence-based characteristics of the LytR-CpsA-Psr proteins.

Results

A comprehensive list of LytR-CpsA-Psr proteins was established, and their phylogenetic distribution and clustering into subgroups was

SUBMITTER: Hubscher J 

PROVIDER: S-EPMC2632651 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature